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Oliver Buchannon
Szczepan Baran

Part scientist, part strategist, full-time translator between what biology knows & what tech can do.


January 2026 | Subtractive Trust

Jan 30, 2026

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7 min read

January 2026 | Subtractive Trust

The advantage is shifting from adding more steps to proving what can be removed by measuring predictivity and using AI inside clear guardrails.

Show Me the Miss Rate

Jan 29, 2026

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9 min read

Show Me the Miss Rate

A Predictivity Ledger that makes evidence auditable, so you can remove steps and use AI without gambling with patient risk

December 2025 | Biology, Loops, and Decision-Grade Trust

Dec 31, 2025

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6 min read

December 2025 | Biology, Loops, and Decision-Grade Trust

As tools accelerate, the differentiator is how we connect mechanistic understanding, real-world feedback, and warranted decisions that hold up under pressure

The Warranty on Our Decisions

Dec 31, 2025

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9 min read

The Warranty on Our Decisions

A 2026 operating rule for biology, AI, and the humans who have to sign their names to both

November 2025 | Rethinking Return

Nov 23, 2025

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7 min read

November 2025 | Rethinking Return

How we define “return” is shifting, from quarterly engagement and platform metrics to durable human outcomes and institutional learning

Who Gets The Return

Nov 23, 2025

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13 min read

Who Gets The Return

Rewriting ROI Around Patients, Not Dashboards

October 2025 | Predictivity as Currency

Oct 26, 2025

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5 min read

October 2025 | Predictivity as Currency

The value of translational science is shifting, from what we prove after the fact to what we can predict before it happens

Landing the Plane

Oct 26, 2025

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13 min read

Landing the Plane

Closing the Loop Between Attrition and Action

This Week’s Ruminations: Patients First, AI Next, and the Messy Middle

Sep 21, 2025

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6 min read

This Week’s Ruminations: Patients First, AI Next, and the Messy Middle

Where patients meet platforms—and the hype meets reality.

The Messy Middle of Innovation

Sep 20, 2025

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11 min read

The Messy Middle of Innovation

Closing the Loop Between Preclinical Tools and Clinical Truths

Patients First. Platforms Second.

Aug 29, 2025

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6 min read

Patients First. Platforms Second.

Ruminations & Ramblings is a new series on the future of drug development—where scientists, executives, and investors meet at the messy middle to ask harder questions and chase fewer myths.

Innovation to Impact;
Ruminations & Ramblings

From idea to impact: candid reflections and sharp provocations on the real journey of innovation in drug development.