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January 2026 | Subtractive Trust

Jan 30, 2026

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7 min read

January 2026 | Subtractive Trust

The advantage is shifting from adding more steps to proving what can be removed by measuring predictivity and using AI inside clear guardrails.

Szczepan Baran
Brian Berridge
Nick Kelley
Szczepan Baran, Brian Berridge, Nick Kelley
Show Me the Miss Rate

Jan 29, 2026

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9 min read

Show Me the Miss Rate

A Predictivity Ledger that makes evidence auditable, so you can remove steps and use AI without gambling with patient risk

Szczepan Baran
Szczepan Baran
Should you make an AI resolution for the AI revolution?

Jan 29, 2026

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9 min read

Should you make an AI resolution for the AI revolution?

Realities of using – or not using – AI for life science

Nick Kelley
Nick Kelley
It’s time for subtractive innovation in drug development

Jan 29, 2026

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10 min read

It’s time for subtractive innovation in drug development

A dog wagging the tail strategy

Brian Berridge
Brian Berridge
December 2025 | Biology, Loops, and Decision-Grade Trust

Dec 31, 2025

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6 min read

December 2025 | Biology, Loops, and Decision-Grade Trust

As tools accelerate, the differentiator is how we connect mechanistic understanding, real-world feedback, and warranted decisions that hold up under pressure

Szczepan Baran
Brian Berridge
Nick Kelley
Szczepan Baran, Brian Berridge, Nick Kelley
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Innovation to Impact;
Ruminations & Ramblings

From idea to impact: candid reflections and sharp provocations on the real journey of innovation in drug development.