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April 2026 | De-Risking What Matters

Apr 30, 2026

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4 min read

April 2026 | De-Risking What Matters

Drug development improves when benefit and harm are quantified earlier, new data are generated for a defined purpose, and every tool is tied to a real decision.

Szczepan Baran
Brian Berridge
Nick Kelley
Szczepan Baran, Brian Berridge, Nick Kelley
Your Pipeline Dies in the Overlap

Apr 8, 2026

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5 min read

Your Pipeline Dies in the Overlap

A practical way to fund only the data that changes decisions, using three curves and one rule: reduce overlap or stop spending

Szczepan Baran
Szczepan Baran
90% of clinical drug development still fails – will AI help to de-risk trials?   Do we have the right data to enable it to do so?

Apr 8, 2026

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5 min read

90% of clinical drug development still fails – will AI help to de-risk trials? Do we have the right data to enable it to do so?

Yes AI can reduce costs and accelerate timelines, but can it help us make better decisions?

Nick Kelley
Nick Kelley
“Drug Development is a Math Problem”

Apr 8, 2026

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7 min read

“Drug Development is a Math Problem”

Strategies for better predictions

Brian Berridge
Brian Berridge
January 2026 | Subtractive Trust

Jan 30, 2026

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7 min read

January 2026 | Subtractive Trust

The advantage is shifting from adding more steps to proving what can be removed by measuring predictivity and using AI inside clear guardrails.

Szczepan Baran
Brian Berridge
Nick Kelley
Szczepan Baran, Brian Berridge, Nick Kelley
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Innovation to Impact;
Ruminations & Ramblings

From idea to impact: candid reflections and sharp provocations on the real journey of innovation in drug development.