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The Horse is Out of the Barn

The Horse is Out of the Barn

Clinical barriers to preclinical success

Aug 14, 2026

•

5 min read

The Context of Use Conundrum

The Context of Use Conundrum

A scoping challenge

Aug 2, 2026

•

7 min read

Patients First. Platforms Second.

September 2025 Issue

Patients First. Platforms Second.

Ruminations & Ramblings is a new series on the future of drug development—where scientists, executives, and investors meet at the messy middle to ask harder questions and chase fewer myths.

Aug 29, 2025

•

6 min read

Blissful Ignorance

Blissful Ignorance

"Filling the void"

Jul 26, 2026

•

6 min read

April 2026 | De-Risking What Matters

April 2026 | De-Risking What Matters

Drug development improves when benefit and harm are quantified earlier, new data are generated for a defined purpose, and every tool is tied to a real decision.

Apr 30, 2026

•

4 min read

In vitro

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The Horse is Out of the Barn

Clinical barriers to preclinical success

Aug 14, 2026

•

5 min read

Brian Berridge
Brian Berridge
The Horse is Out of the Barn

The Context of Use Conundrum

A scoping challenge

Aug 2, 2026

•

7 min read

Brian Berridge
Brian Berridge
The Context of Use Conundrum

Blissful Ignorance

"Filling the void"

Jul 26, 2026

•

6 min read

Brian Berridge
Brian Berridge
Blissful Ignorance

April 2026 | De-Risking What Matters

Drug development improves when benefit and harm are quantified earlier, new data are generated for a defined purpose, and every tool is tied to a real decision.

Apr 30, 2026

•

4 min read

Szczepan Baran
Brian Berridge
Nick Kelley
Szczepan Baran, +2
April 2026 | De-Risking What Matters

Your Pipeline Dies in the Overlap

A practical way to fund only the data that changes decisions, using three curves and one rule: reduce overlap or stop spending

Apr 8, 2026

•

5 min read

Szczepan Baran
Szczepan Baran
Your Pipeline Dies in the Overlap

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Innovation to Impact;
Ruminations & Ramblings

From idea to impact: candid reflections and sharp provocations on the real journey of innovation in drug development.