The Horse is Out of the Barn

Clinical barriers to preclinical success

The Context of Use Conundrum

A scoping challenge

Blissful Ignorance

"Filling the void"

April 2026 | De-Risking What Matters

Drug development improves when benefit and harm are quantified earlier, new data are generated for a defined purpose, and every tool is tied to a real decision.

“Drug Development is a Math Problem”

Strategies for better predictions

January 2026 | Subtractive Trust

The advantage is shifting from adding more steps to proving what can be removed by measuring predictivity and using AI inside clear guardrails.

It’s time for subtractive innovation in drug development

A dog wagging the tail strategy

December 2025 | Biology, Loops, and Decision-Grade Trust

As tools accelerate, the differentiator is how we connect mechanistic understanding, real-world feedback, and warranted decisions that hold up under pressure

Better Forward Than Back

November 2025 | Rethinking Return

How we define “return” is shifting, from quarterly engagement and platform metrics to durable human outcomes and institutional learning

“The Business of Science”

Character Flaws and ROIs

October 2025 | Predictivity as Currency

The value of translational science is shifting, from what we prove after the fact to what we can predict before it happens

Attrition: The existential threat

Sustainable drug development at risk

This Week’s Ruminations: Patients First, AI Next, and the Messy Middle

Where patients meet platforms—and the hype meets reality.

The Tail is Wagging the Dog

Innovation without direction probably isn’t innovation