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January 2026 | Subtractive Trust

January 2026 | Subtractive Trust

The advantage is shifting from adding more steps to proving what can be removed by measuring predictivity and using AI inside clear guardrails.

Jan 30, 2026

•

7 min read

Show Me the Miss Rate

Show Me the Miss Rate

A Predictivity Ledger that makes evidence auditable, so you can remove steps and use AI without gambling with patient risk

Jan 29, 2026

•

9 min read

Drug Development

+4

Patients First. Platforms Second.

September 2025 Issue

Patients First. Platforms Second.

Ruminations & Ramblings is a new series on the future of drug development—where scientists, executives, and investors meet at the messy middle to ask harder questions and chase fewer myths.

Aug 29, 2025

•

6 min read

Should you make an AI resolution for the AI revolution?

Should you make an AI resolution for the AI revolution?

Realities of using – or not using – AI for life science

Jan 29, 2026

•

9 min read

AI

+4

It’s time for subtractive innovation in drug development

It’s time for subtractive innovation in drug development

A dog wagging the tail strategy

Jan 29, 2026

•

10 min read

clinical trials

+3

Most Popular

Latest Posts

January 2026 | Subtractive Trust

The advantage is shifting from adding more steps to proving what can be removed by measuring predictivity and using AI inside clear guardrails.

Jan 30, 2026

•

7 min read

Szczepan Baran
Brian Berridge
Nick Kelley
Szczepan Baran, +2
January 2026 | Subtractive Trust

Show Me the Miss Rate

A Predictivity Ledger that makes evidence auditable, so you can remove steps and use AI without gambling with patient risk

Jan 29, 2026

•

9 min read

Szczepan Baran
Szczepan Baran
Show Me the Miss Rate

Should you make an AI resolution for the AI revolution?

Realities of using – or not using – AI for life science

Jan 29, 2026

•

9 min read

Nick Kelley
Nick Kelley
Should you make an AI resolution for the AI revolution?

It’s time for subtractive innovation in drug development

A dog wagging the tail strategy

Jan 29, 2026

•

10 min read

Brian Berridge
Brian Berridge
It’s time for subtractive innovation in drug development

December 2025 | Biology, Loops, and Decision-Grade Trust

As tools accelerate, the differentiator is how we connect mechanistic understanding, real-world feedback, and warranted decisions that hold up under pressure

Dec 31, 2025

•

6 min read

Szczepan Baran
Brian Berridge
Nick Kelley
Szczepan Baran, +2
December 2025 | Biology, Loops, and Decision-Grade Trust

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Innovation to Impact;
Ruminations & Ramblings

From idea to impact: candid reflections and sharp provocations on the real journey of innovation in drug development.